男性不育症新检测方法

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无法怀孕的夫妇可能很快就能更好地查明问题的原因。根据《人类生殖》杂志上的一份报告,一组美国和日本科学家开发出一种男性不育症检测方法,该方法优于传统的精液分析。

这种名为精子泛素标签免疫分析法 (SUTI) 的新方法,旨在搜索精子细胞中一种名为泛素的小蛋白质,泛素是损伤或缺陷的指标。研究人员使用泛素抗体筛选了来自 17 名不育患者和 2 名可育捐赠者的精子,在某些情况下证实了之前的诊断,并在另一些情况下揭示了之前无法解释的不育原因。“泛素似乎是精液异常的通用标志物,可以识别各种精子缺陷以及精液中的污染物,”俄勒冈健康与科学大学的团队成员 Peter Sutovsky 说。“在大约五分之一的夫妇中,目前的方法无法确定病因,”他补充道。“SUTI 将能够在至少一部分病例中提供答案。”

更重要的是,团队成员 Gerald Schatten 指出,SUTI 甚至可能在治疗中发挥积极作用。“既然我们现在知道一种与缺陷精子相关的特定蛋白质,并且我们拥有针对它的抗体,那么我们就有可能开发出一种技术,从精液样本中去除大部分真正有缺陷的精子,用于[体外受精]或卵胞浆内单精子注射 (ICSI)——即通过注射单个精子使卵子受精的过程。”

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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