新型化合物控制体重增加

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我们都听过衣着暴露的代言人在深夜电视上对快速减肥补品做出虚假宣传。但在今天早些时候在线出版的《美国国家科学院院刊》上,研究人员描述了一种听起来像是真材实料的东西——至少对于小鼠而言是这样。怀特海生物医学研究所的哈维·洛迪什及其同事发现了一种新型化合物,这种化合物可以导致喂食不限量高脂肪和高糖饮食的小鼠体重显著减轻。这种化合物名为gAcrp30,是Acrp30蛋白的一个片段。大多数减肥药物的作用原理是通过吸收肠道中的脂肪酸,或者通过抑制脂肪酸的分解,使其排出体外而不是储存起来。相比之下,gAcrp30实际上可以促使肌肉更快地燃烧脂肪酸。

用该化合物治疗的小鼠显示,游离脂肪酸水平显著降低,葡萄糖和甘油三酯水平也降低。此外,每日低剂量的gAcrp30使小鼠能够保持体重不增加,尽管它们吃的是自助餐式饮食。虽然结果很有希望,但现在还不要熬夜寻找电话号码来拨打。“还需要进行更多的研究,以确定这种物质是否可以用于人类,作为减肥的辅助手段,”洛迪什评论道。“成千上万患有糖尿病等多种相关健康问题的肥胖患者迫切需要这种疗法。”

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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