新的艾滋病疫苗保护猴子免受病毒侵害

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研究人员开发出一种新的、易于管理的疫苗,可以保护猴子免受艾滋病病毒侵害,使科学家们离研制出有效的人类疫苗更近一步。这项发现发表在9月7日出版的《细胞》杂志上。

这种新型疫苗由耶鲁大学的约翰·K·罗斯和他的同事设计,使用一种常见的牲畜病毒——水疱性口炎病毒的弱化形式,将艾滋病病毒蛋白输送到体内。这些蛋白质刺激了七只接受疫苗的猴子的强烈免疫反应:在研究人员用艾滋病病毒感染它们14个月后,接种疫苗的猴子仍然没有感染艾滋病。相比之下,八只未接种疫苗的猴子中有七只在感染后约五个月患上了这种疾病。

基于VSV的疫苗比最近描述的DNA疫苗方法具有优势,因为它不需要多次注射。罗斯报告说,它可以作为滴鼻剂给药。“在发展中国家和受艾滋病毒和艾滋病严重影响的地区,为数百万人注射DNA疫苗是不切实际且非常昂贵的,”他指出。“基于VSV的疫苗将是其他正在测试的疫苗的一种经济高效且同样成功的替代方案。我们对此感到非常兴奋。”

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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