疟疾和癌细胞屈服于相同的大蒜化合物

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大蒜可能无法抵御吸血鬼,但科学研究表明它确实提供了许多健康益处,表现出抗真菌和抗菌特性,并且似乎有助于降低心血管疾病和某些癌症的风险。动物研究也表明它可以对抗疟疾。然而,大蒜究竟是如何对抗如此不同的敌人,已经被证明有些难以理解。为了这个目的,昨天在亚特兰大举行的美国热带医学和卫生学会年会上宣布的发现提供了一些见解。根据该报告,疟疾细胞和癌细胞都屈服于相同的大蒜化合物。

为了探究大蒜的保护能力,多伦多大学的伊恩·克兰德尔和他的同事们专注于被称为二硫化物的化合物,已知这些化合物具有抗真菌、抗菌和抗癌特性。该团队测试了11种合成二硫化物化合物对感染疟疾的细胞和癌细胞的影响。他们发现,那些有效对抗疟疾细胞的化合物,也消灭了癌细胞。


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克兰德尔怀疑它们共同的易感性可能源于它们对被称为谷胱甘肽系统的依赖。在这个细胞系统中,抗氧化剂和解毒剂谷胱甘肽被还原并储存起来以备后用,当需要它来吸收损伤时。快速繁殖的细胞,例如那些受癌症或疟疾侵袭的细胞,特别依赖于这种谷胱甘肽系统,因为毒素是新陈代谢的天然副产品。事实证明,大蒜二硫化物大蒜烯会抑制谷胱甘肽的还原,这可能对感染疟疾的细胞和癌细胞来说是死刑判决。

展望未来,克兰德尔希望这种二硫化物化合物有一天能用于治疗疟疾和癌症。然而,目前,他和他的同事们必须忍受“臭玫瑰”的气味才能工作。“这东西闻起来像大蒜吗?嗯,每次我们在实验室打开一瓶它,每个人都跑了。”

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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