生长替代血管

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在组织培养中生长的血管可能有一天会帮助治愈破碎的心脏。 根据昨天在俄亥俄州举行的 2000 年生物微机电系统和生物医学纳米技术世界大会上公布的初步结果,研究人员已朝着在实验室中培育替代血管迈出了第一步,以便移植到心脏病发作患者的体内。

俄亥俄州立大学研究员尼卡诺·摩尔多万及其同事设想的宏伟计划包括将从血管内膜或内皮层采集的细胞播种在形状像毛细血管的硅模具中。 然后,由此产生的培养物将通过称为“血管芯片”的微型机器输送到心脏。 一旦进入内部,它们就可以开始修复心脏病发作造成的损害。 摩尔多万推测说:“我们可能无法使组织恢复到原来的形态,但我们可以尝试使其血管再生,使心脏再次跳动,或者至少通过创造新的毛细血管来防止心脏组织死亡,这些毛细血管将尽快提供血液和氧气。”

到目前为止,研究人员已经克服了第一个障碍:证明种子细胞可以在雕刻在柔软、透明凝胶中的凹槽中二维生长。 尽管该计划极其复杂,但摩尔多万仍然抱有希望。 他评论说:“我们不得不处理大量的推测或假设,但我们的方法似乎非常有希望。 “一旦我们证明我们可以在硅上或硅内部以特定的三维形状生长细胞,那么我们希望回到组织。”

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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