为了您大脑的健康而锻炼

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根据一项新的研究,除了保持身体健康外,锻炼可能还可以保护您的大脑。发表在最新一期期刊Genes and Development上的研究表明,跑步可以促进患有神经退行性疾病的动物的脑细胞存活。先前的研究表明,跑步可以促进正常小鼠的脑细胞生长。然而,在新的研究中,科学家们研究了患有类似于共济失调毛细血管扩张症 (A-T) 的小鼠,这种疾病在人类中会导致运动控制丧失,通常使患者卧床不起。(虽然罕见,但 A-T 与阿尔茨海默病等疾病具有共同的特性。)他们发现,跑步的 A-T 小鼠比不跑步的同类表现出更高的细胞存活率。“在久坐不动的 A-T 小鼠中,似乎大多数新生的脑细胞都会死亡,”团队成员卡罗琳·巴洛指出。“我们并不完全理解这一点,但这可能与无法应对氧化应激有关。跑步似乎“拯救”了许多原本会死亡的细胞,”她继续说道。“这表明保持活跃可能有助于延缓神经退行性疾病的进展。”

研究人员希望进一步的调查将揭示锻炼究竟如何帮助脑细胞存活。“它一定是改变了大脑化学物质——或许改变了特定激素或生长因子的水平,”巴洛沉思道。“如果我们能够确定导致跑步效果的特定分子,这些分子应该会指出治疗 A-T 和其他神经退行性疾病的新药物策略。”

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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