清除阿爾茨海默氏症斑塊

加入我们的科学爱好者社群!


关于支持科学新闻报道

如果您喜欢这篇文章,请考虑通过支持我们屡获殊荣的新闻报道 订阅。通过购买订阅,您正在帮助确保未来能够继续产出关于塑造我们当今世界的发现和想法的具有影响力的报道。


研究人员用培育出的患有阿尔茨海默氏症相关斑块的小鼠进行实验,成功清除了这些动物大脑中的斑块。 之前的研究表明,疫苗可以预防斑块的形成,但这项发表在三月份《自然医学》杂志上的新研究,首次证明了现有斑块的清除。 马萨诸塞州总医院的布莱恩·巴克斯凯及其同事发现,通过手术将抗斑块抗体直接应用于动物大脑,仅在几天内就清除了 70% 的斑块。 同样值得注意的是,该团队首次使用一种名为多光子显微镜的新设备,在活体动物身上观察到斑块。

清除的斑块附近的神经元究竟会受到怎样的影响尚不清楚,但进一步的研究可能会阐明这个问题。 团队成员布拉德利·海曼评论说:“一旦我们能看到斑块在哪里,我们也可以询问它们区域内的神经元是否健康。” “真正的关键是了解如何改善大脑功能。”

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

More by Kate Wong
© . All rights reserved.