血液标志物可能预示自闭症和精神发育迟滞

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科学家们已经确定了可能与儿童后期自闭症和精神发育迟滞发展相关的血液标志物。 这项新的研究将发表在五月份的神经病学年鉴上,可能有助于更早、更准确地诊断和改进这些疾病的疗法。

国家神经疾病与卒中研究所的卡琳·B·尼尔森 (Karin B. Nelson) 和她的同事研究了来自正常发育儿童以及后来发展为自闭症、精神发育迟滞或脑瘫儿童的档案新生儿血液样本。 该团队发现,与另外两组儿童的血液相比,后来发展为自闭症或精神发育迟滞的儿童血液中神经生长因子的水平显著升高。

神经生长因子在胚胎发育过程中中枢神经系统的形成中起着关键作用,包括产生和组织脑细胞等。 研究人员提出,这些蛋白质的过量可能因此扰乱细胞在早期神经系统发育过程中经历的正常周期。 然而,自闭症等疾病发展的许多生物学和遗传机制仍然未知。 因此,尼尔森和她的同事计划在未来继续进行类似的研究。

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

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