揭开癌症的根源

最近的证据挑战了长期以来关于细胞如何转变为恶性的理论——并提出了在肿瘤扩散前阻止它们的新方法

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Aneuploidy Precedes and Segregates with Chemical Carcinogenesis. Peter Duesberg, Ruhong Li, David Rasnick, Charlotte Rausch, Andreas Willer, Alwin Kraemer, George Yerganian and Ruediger Hehlmann in Cancer Genetics and Cytogenetics, Vol. 119, No. 2, pages 83-93; June 2000.

Chromosome Segregation and Cancer: Cutting through the Mystery. Prasad V. Jallepalli and Cristoph Lengauer in Nature Reviews Cancer, Vol. 1, No. 2, pages 109-117; November 2001.

Rules for Making Human Tumor Cells. William C. Hahn and Robert A. Weinberg in New England Journal of Medicine, Vol. 347, No. 20, pages 1593-1603; November 14, 2002.

Multiple Mutations and Cancer. Lawrence A. Loeb, Keith R. Loeb and Jon P. Anderson in Proceedings of the National Academy of Sciences USA, Vol. 100, No. 3, pages 776-781; February 4, 2003.

W. Wayt Gibbs is a contributing editor for 大众科学 based in Seattle. He also works as a scientific editor at Intellectual Ventures.

More by W. Wayt Gibbs
大众科学 Magazine Vol 289 Issue 1This article was originally published with the title “Untangling the Roots of Cancer” in 大众科学 Magazine Vol. 289 No. 1 ()
doi:10.1038/scientificamerican072003-6BMnQ2PyGvy0wPgkseeJii
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