冷冻卵子以保存生育能力

加入我们的科学爱好者社区!


关于支持科学新闻报道

如果您喜欢这篇文章,请考虑通过以下方式支持我们屡获殊荣的新闻报道 订阅。 通过购买订阅,您将帮助确保未来能够继续提供关于塑造我们当今世界的发现和思想的具有影响力的报道。


对于因医疗治疗或卵巢早衰而面临生育能力丧失风险的女性来说,提前冷冻一些卵子可以为她们保留生育孩子的可能性。 但是,人类卵子的冷冻保存已被证明是一项极其难以掌握的技术。 事实上,自从研究人员首次尝试这项技术以来的15年里,只诞生了大约30个婴儿。 然而,今天在《人类生殖》杂志上报道的结果可能带来新的希望。 根据新的研究,调整冷冻技术使科学家能够将卵子存活率提高一倍以上。

卵子通常在冷冻过程中会退化,因为它们没有充分脱水。 过量的水会形成冰晶,从而刺穿卵子的膜并杀死细胞。 博洛尼亚大学的拉法埃拉·法布里及其同事发现,增加卵子暴露于化学保护剂的时间以及增加冷冻溶液中糖的含量可以改善脱水效果。 事实上,他们能够将卵子存活率从 34% 提高到高达 82%。 随后通过将单个精子注射到卵子中(卵胞浆内单精子注射,ICSI)进行的受精获得了 57% 的成功率,与新鲜卵母细胞的成功率相当。

法布里指出:“我们的下一步将是进一步提高卵母细胞在解冻后的存活率。” “但我们的研究已经证实,人类卵母细胞是可以冷冻保存的,而卵胞浆内单精子注射可能是实现令人满意的受精的有效方法。”

Kate Wong is an award-winning science writer and senior editor at 大众科学 focused on evolution, ecology, anthropology, archaeology, paleontology and animal behavior. She is fascinated by human origins, which she has covered for more than 25 years. Recently she has become obsessed with birds. Her reporting has taken her to caves in France and Croatia that Neandertals once called home, to the shores of Kenya's Lake Turkana in search of the oldest stone tools in the world, to Madagascar on an expedition to unearth ancient mammals and dinosaurs, to the icy waters of Antarctica, where humpback whales feast on krill, and on a "Big Day" race around the state of Connecticut to find as many bird species as possible in 24 hours. Kate is co-author, with Donald Johanson, of Lucy's Legacy: The Quest for Human Origins. She holds a bachelor of science degree in biological anthropology and zoology from the University of Michigan. Follow Wong on X (formerly Twitter) @katewong

More by Kate Wong
© . All rights reserved.